Anti-Ma2-antibody-associated encephalitis: An atypical paraneoplastic neurologic syndrome

Anti-Ma2-antibody-associated encephalitis: An atypical paraneoplastic neurologic syndrome

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Paraneoplastic syndromes are a heterogeneous group of conditions affecting cancer patients, where the signs and symptoms are not owing to the local effects of the tumour but instead owing to humoral or Milk Pot immunologic effects.We describe an unusual presentation of a paraneoplastic neurologic syndrome presenting with predominant involvement of the hypothalamus and deep grey nuclei secondary to an anterior mediastinal germinoma and associated Above Ground Product (Heaters) with anti-Ma2 antibody.